Data privacy is a critical challenge in modern medical workflows as the adoption of electronic patient records has grown rapidly. Stringent data protection regulations limit access to clinical records for training and integrating machine learning models that have shown promise in improving diagnostic accuracy and personalized care outcomes. Synthetic data offers a promising alternative; however, current generative models either struggle with time-series data or lack formal privacy guaranties. In this paper, we enhance a state-of-the-art time-series generative model to better handle longitudinal clinical data while incorporating quantifiable privacy safeguards. Using real data from chronic kidney disease and ICU patients, we evaluate our method through statistical tests, a Train-on-Synthetic-Test-on-Real (TSTR) setup, and expert clinical review. Our non-private model (Augmented TimeGAN) outperforms transformer- and flow-based models on statistical metrics in several datasets, while our private model (DP-TimeGAN) maintains a mean authenticity of 0.778 on the CKD dataset, outperforming existing state-of-the-art models on the privacy-utility frontier. Both models achieve performance comparable to real data in clinician evaluations, providing robust input data necessary for developing models for complex chronic conditions without compromising data privacy.

Deterministic Lateral Displacement (DLD) devices are widely used in microfluidics for label-free, size-based separation of particles and cells, with particular promise in isolating circulating tumor cells (CTCs) for early cancer diagnostics. This study focuses on the optimization of DLD design parameters, such as row shift fraction, post size, and gap distance, to enhance the selective isolation of lung cancer cells based on their physical properties. To overcome the challenges of rare CTC detection and reduce reliance on computationally intensive simulations, machine learning models including gradient boosting, k-nearest neighbors, random forest, and multilayer perceptron (MLP) regressors are employed. Trained on a large, numerically validated dataset, these models predict particle trajectories and identify optimal device configurations, enabling high-throughput and cost-effective DLD design. Beyond trajectory prediction, the models aid in isolating critical design variables, offering a systematic, data-driven framework for automated DLD optimization. This integrative approach advances the development of scalable and precise microfluidic systems for cancer diagnostics, contributing to the broader goals of early detection and personalized medicine.

The proliferation of Large Language Model (LLM) architectures presents a fundamental challenge: valuable, task-specific behaviors learned through fine-tuning methods like Low-Rank Adaptation (LoRA) are effectively trapped within their source model's architecture, herein referred to architectural lock-in. Existing transfer methods attempt to bridge this gap by aligning the static weight spaces of models, a brittle and indirect approach that relies on tenuous correlations between parameter geometries. This paper introduces a fundamentally different and more direct paradigm: the Cartridge Activation Space Transfer (CAST), a novel framework that liberates LoRA-encoded behaviors by learning a direct, nonlinear mapping between the activation manifolds, the geometric structures formed by the model's internal neuron activations, of two distinct LLM architectures. CAST treats a pre-trained LoRA as a frozen "behavioral kernel." It learns a set of lightweight, bidirectional projection heads that translate the target model's activation stream into the source model's latent space, apply the frozen kernel, and project the result back. This process, trained on a general text corpus without any task-specific data, effectively decouples the learned skill from the source architecture. We demonstrate that CAST enables true "zero-shot" translation of any standard LoRA adapter. Our experiments, including transfers between heterogeneous model families like Llama-2 and Mistral, show that CAST-translated adapters achieve 85-95\% of the performance of a LoRA fully retrained on the target model, quantitatively outperforming current weight-space transfer techniques and establishing a new state-of-the-art in model interoperability.

Generative artificial intelligence is developing rapidly, impacting humans' interaction with information and digital media. It is increasingly used to create deceptively realistic misinformation, so lawmakers have imposed regulations requiring the disclosure of AI-generated content. However, only little is known about whether these labels reduce the risks of AI-generated misinformation. Our work addresses this research gap. Focusing on AI-generated images, we study the implications of labels, including the possibility of mislabeling. Assuming that simplicity, transparency, and trust are likely to impact the successful adoption of such labels, we first qualitatively explore users' opinions and expectations of AI labeling using five focus groups. Second, we conduct a pre-registered online survey with over 1300 U.S. and EU participants to quantitatively assess the effect of AI labels on users' ability to recognize misinformation containing either human-made or AI-generated images. Our focus groups illustrate that, while participants have concerns about the practical implementation of labeling, they consider it helpful in identifying AI-generated images and avoiding deception. However, considering security benefits, our survey revealed an ambiguous picture, suggesting that users might over-rely on labels. While inaccurate claims supported by labeled AI-generated images were rated less credible than those with unlabeled AI-images, the belief in accurate claims also decreased when accompanied by a labeled AI-generated image. Moreover, we find the undesired side effect that human-made images conveying inaccurate claims were perceived as more credible in the presence of labels.

What happens when a rideshare driver is suddenly locked out of the platform connecting them to riders, wages, and daily work? Deactivation-the abrupt removal of gig workers' platform access-typically occurs through arbitrary AI and algorithmic decisions with little explanation or recourse. This represents one of the most severe forms of algorithmic control and often devastates workers' financial stability. Recent U.S. state policies now mandate appeals processes and recovering compensation during the period of wrongful deactivation based on past earnings. Yet, labor organizers still lack effective tools to support these complex, error-prone workflows. We designed FareShare, a computational tool automating lost wage estimation for deactivated drivers, through a 6 month partnership with the State of Washington's largest rideshare labor union. Over the following 3 months, our field deployment of FareShare registered 178 account signups. We observed that the tool could reduce lost wage calculation time by over 95%, eliminate manual data entry errors, and enable legal teams to generate arbitration-ready reports more efficiently. Beyond these gains, the deployment also surfaced important socio-technical challenges around trust, consent, and tool adoption in high-stakes labor contexts.

Accurate dynamic modeling is critical for autonomous racing vehicles, especially during high-speed and agile maneuvers where precise motion prediction is essential for safety. Traditional parameter estimation methods face limitations such as reliance on initial guesses, labor-intensive fitting procedures, and complex testing setups. On the other hand, purely data-driven machine learning methods struggle to capture inherent physical constraints and typically require large datasets for optimal performance. To address these challenges, this paper introduces the Fine-Tuning Hybrid Dynamics (FTHD) method, which integrates supervised and unsupervised Physics-Informed Neural Networks (PINNs), combining physics-based modeling with data-driven techniques. FTHD fine-tunes a pre-trained Deep Dynamics Model (DDM) using a smaller training dataset, delivering superior performance compared to state-of-the-art methods such as the Deep Pacejka Model (DPM) and outperforming the original DDM. Furthermore, an Extended Kalman Filter (EKF) is embedded within FTHD (EKF-FTHD) to effectively manage noisy real-world data, ensuring accurate denoising while preserving the vehicle's essential physical characteristics. The proposed FTHD framework is validated through scaled simulations using the BayesRace Physics-based Simulator and full-scale real-world experiments from the Indy Autonomous Challenge. Results demonstrate that the hybrid approach significantly improves parameter estimation accuracy, even with reduced data, and outperforms existing models. EKF-FTHD enhances robustness by denoising real-world data while maintaining physical insights, representing a notable advancement in vehicle dynamics modeling for high-speed autonomous racing.

We explore the application of machine learning algorithms to predict the suitability of Russet potato clones for advancement in breeding trials. Leveraging data from manually collected trials in the state of Oregon, we investigate the potential of a wide variety of state-of-the-art binary classification models. We conduct a comprehensive analysis of the dataset that includes preprocessing, feature engineering, and imputation to address missing values. We focus on several key metrics such as accuracy, F1-score, and Matthews correlation coefficient (MCC) for model evaluation. The top-performing models, namely the multi-layer perceptron (MLPC), histogram-based gradient boosting classifier (HGBC), and a support vector machine (SVC), demonstrate consistent and significant results. Variable selection further enhances model performance and identifies influential features in predicting trial outcomes. The findings emphasize the potential of machine learning in streamlining the selection process for potato varieties, offering benefits such as increased efficiency, substantial cost savings, and judicious resource utilization. Our study contributes insights into precision agriculture and showcases the relevance of advanced technologies for informed decision-making in breeding programs.

With the advent of the Post-Moore era, the scientific community is faced with the challenge of addressing the demands of current data-intensive machine learning applications, which are the cornerstone of urgent analytics in distributed computing. Quantum machine learning could be a solution for the increasing demand of urgent analytics, providing potential theoretical speedups and increased space efficiency. However, challenges such as (1) the encoding of data from the classical to the quantum domain, (2) hyperparameter tuning, and (3) the integration of quantum hardware into a distributed computing continuum limit the adoption of quantum machine learning for urgent analytics. In this work, we investigate the use of Edge computing for the integration of quantum machine learning into a distributed computing continuum, identifying the main challenges and possible solutions.

Acute compartment syndrome (ACS) is an orthopedic emergency, caused by elevated pressure within a muscle compartment, that leads to permanent tissue damage and eventually death. Diagnosis of ACS relies heavily on patient-reported symptoms, a method that is clinically unreliable and often supplemented with invasive intracompartmental pressure measurements that can malfunction in motion settings. This study proposes an objective and noninvasive diagnostic for ACS. The device detects ACS through a random forest machine learning model that uses surrogate pressure readings from force-sensitive resistors (FSRs) placed on the skin. To validate the diagnostic, a data set containing FSR measurements and the corresponding simulated intracompartmental pressure was created for motion and motionless scenarios. The diagnostic achieved up to 98% accuracy. The device excelled in key performance metrics, including sensitivity and specificity, with a statistically insignificant performance difference in motion present cases. Manufactured for 73 USD, our device may be a cost-effective solution. These results demonstrate the potential of noninvasive ACS diagnostics to meet clinical accuracy standards in real world settings.

The rapid advancement of Large AI Models (LAIMs), particularly diffusion models and large language models, has marked a new era where AI-generated multimedia is increasingly integrated into various aspects of daily life. Although beneficial in numerous fields, this content presents significant risks, including potential misuse, societal disruptions, and ethical concerns. Consequently, detecting multimedia generated by LAIMs has become crucial, with a marked rise in related research. Despite this, there remains a notable gap in systematic surveys that focus specifically on detecting LAIM-generated multimedia. Addressing this, we provide the first survey to comprehensively cover existing research on detecting multimedia (such as text, images, videos, audio, and multimodal content) created by LAIMs. Specifically, we introduce a novel taxonomy for detection methods, categorized by media modality, and aligned with two perspectives: pure detection (aiming to enhance detection performance) and beyond detection (adding attributes like generalizability, robustness, and interpretability to detectors). Additionally, we have presented a brief overview of generation mechanisms, public datasets, and online detection tools to provide a valuable resource for researchers and practitioners in this field. Furthermore, we identify current challenges in detection and propose directions for future research that address unexplored, ongoing, and emerging issues in detecting multimedia generated by LAIMs. Our aim for this survey is to fill an academic gap and contribute to global AI security efforts, helping to ensure the integrity of information in the digital realm. The project link is https://github.com/Purdue-M2/Detect-LAIM-generated-Multimedia-Survey.